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Endothelial cell modulation of primary platelet hemostasis
1Division of Pediatric Hematology/Oncology, New York Hospital-Cornell Medical Center, New York 10021.
Rheology has profound effects on the rate, structure, and modulation of primary hemostasis. Many of these effects can be studied via real-time, epifluorescence videomicroscopy of platelet adhesion-aggregation to a site of injury to an endothelial cell monolayer exposed to flowing blood. In particular, with the model described, endothelial cells can be shown to be a significant modulator of platelet function at an injury site.
Rheology has profound effects on the rate, structure, and modulation of primary hemostasis. Many of these effects can be studied via real-time, epifluorescence videomicroscopy of platelet adhesion-aggregation to a site of injury to an endothelial cell monolayer exposed to flowing blood. In particular, with the model described, endothelial cells can be shown to be a significant modulator of platelet function at an injury site.