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The roles of microRNAs played in lung diseases via regulating cell apoptosis

Qiaoling Huang1,2, Li Chen1,2, Qinqin Bai1,2

  • 1Department of Public Health Laboratory Sciences, College of Public Health, Hengyang Medical School, University of South China, 28 West Changsheng Rd, Hengyang, 421001, Hunan, China.

Molecular and Cellular Biochemistry
|August 16, 2021
PubMed

Insights

MicroRNAs regulate lung cell apoptosis, impacting lung disease development. This review explores how these small RNAs influence host cell death in various lung conditions.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Pulmonary Medicine

Background:

  • MicroRNAs (miRNAs) are key regulators of cellular functions like apoptosis.
  • Lung injury can result from pathogens, physical, or chemical factors.
  • miRNAs and lung cell apoptosis are implicated in lung disease progression.

Purpose of the Study:

  • To review the role of miRNAs in lung disease development.
  • To elucidate how miRNAs regulate host cell apoptosis in the context of lung diseases.

Main Methods:

  • Literature review of studies on miRNAs and lung cell apoptosis.
  • Analysis of miRNA-mediated regulation of apoptosis pathways in lung diseases.

Main Results:

  • miRNAs significantly influence apoptosis in lung cells.
  • Dysregulation of specific miRNAs is linked to various lung pathologies.
  • miRNAs modulate key apoptotic pathways relevant to lung disease.

Conclusions:

  • miRNAs are critical players in the pathogenesis of lung diseases via apoptosis.
  • Targeting miRNAs offers potential therapeutic strategies for lung conditions.
Keywords:
ApoptosisLungMicroRNA

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