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Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade

Soyoung Son1, Jung Min Shin2, Sol Shin3

  • 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, 16419, Republic of Korea.

Biomaterials
|August 16, 2021
PubMed
Summary

Repurposed macitentan (M-NPs) reorganize the tumor microenvironment (TME) to enhance immune checkpoint therapy (ICT). This approach improves T cell infiltration and antitumor effects in preclinical models.

Keywords:
Cancer exosomeCancer-associated fibroblastEndothelin receptor antagonistImmune checkpoint therapyNanomedicineTumor microenvironment

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