Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with...

Area of Science:

• Hematology
• Oncology
• Dermatology

Background:

• Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy with aggressive behavior and poor prognosis.
• It is believed to originate from precursor plasmacytoid dendritic cells.

Observation:

• A previously healthy man presented with sudden onset of multiple deep purple skin rashes.
• Sequential computed tomography (CT) scans revealed fusion of skin nodules, leading to diffuse skin thickening, erosions, and crusting.

Findings:

• The case illustrates the rapid and severe cutaneous manifestations of BPDCN.
• Imaging findings showed progressive skin involvement consistent with the neoplasm's advancement.

Implications:

• BPDCN should be included in the differential diagnosis for patients presenting with sudden, rapidly progressing skin rashes or thickening.
• Early consideration of BPDCN can aid in timely diagnosis and management of this aggressive malignancy.