Related Experiment Video

Updated: Oct 23, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

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Trajectories of oral glucose tolerance testing in cystic fibrosis

Monal Patel1,2, Courtney McCracken1, Tanicia Daley1

  • 1Department of Pediatrics, Emory University and Emory + Children's Center for Cystic Fibrosis and Airways Disease Research, Atlanta, Georgia, USA.

Pediatric Pulmonology
|August 17, 2021
PubMed

Insights

Most pediatric cystic fibrosis patients show worsening glucose tolerance over time. Lower lung function is linked to this progression, indicating early CFRD development.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Metabolic disorders

Background:

  • Annual oral glucose tolerance testing (OGTT) screens for cystic fibrosis-related diabetes (CFRD).
  • Understanding glucose homeostasis progression in pediatric cystic fibrosis (CF) is crucial.

Purpose of the Study:

  • Identify patterns of worsening glucose tolerance in pediatric CF patients.
  • Explore the relationship between glucose homeostasis and lung function.

Main Methods:

  • Retrospective cohort study of 63 pediatric CF patients (ages 10-18) without CFRD.
  • Latent class mixture models analyzed 2-hour OGTT glucose (2hrGlu) trajectories.
  • Multivariable linear models adjusted for clinical covariates.

Main Results:

  • Three 2hrGlu trajectories identified: high-to-higher (n=8), low-and-increasing (n=47), and low-and-flat (n=8).
  • 87% of patients showed worsening glucose homeostasis over time.
  • Lower baseline forced expiratory volume in 1-second percent predicted (ppFEV1) was associated with the high-to-higher 2hrGlu trajectory.

Conclusions:

  • Most pediatric CF patients without diabetes exhibit progressive glucose intolerance.
  • Reduced lung function is an early indicator in CFRD development.
Abstract

Keywords:
adolescentscystic fibrosiscystic fibrosis‐related diabetesimpaired glucose toleranceoral glucose tolerance testpulmonary function testing

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