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Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System

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[Lectins in Viscum:a progress review].

Jia-Qi Li¹, Bin Yang¹

¹Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|August 17, 2021

Summary

This summary is machine-generated.

Mistletoe lectins from Viscum plants show anticancer and immune benefits. This review highlights research progress on Chinese Viscum lectins, focusing on extraction, activity, and clinical use.

Keywords:

clinical research extraction and purification lectins mistletoe molecular structure pharmacological efficacy quantitative/qualitative detection toxicity

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A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples

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Area of Science:

Phytochemistry
Immunology
Pharmacology

Background:

Viscum plants, parasitic shrubs, are found globally, with 11 species and one variety in China.
Mistletoe lectins are type II ribosome-inactivating proteins (RIPs) with anticancer and immunoregulatory properties.
Existing research and clinical applications (e.g., Iscucin®) primarily focus on European and South Korean Viscum species.

Purpose of the Study:

To review recent advancements in mistletoe lectins (MLs) from Viscum plants.
To consolidate research on extraction, purification, detection, structure, activities, and toxicity of MLs.
To provide a reference for further research and application of Chinese MLs.

Main Methods:

Literature review of studies on Viscum mistletoe lectins.
Analysis of extraction and purification techniques.
Evaluation of pharmacological activities, toxicities, and clinical applications.

Main Results:

Mistletoe lectins exhibit significant anticancer and immunomodulatory effects.
Progress has been made in understanding MLs' molecular structure and biological activities.
Limited research exists on MLs from Chinese Viscum species compared to European and Korean counterparts.

Conclusions:

Viscum plants in China are a potential source of novel mistletoe lectins.
Further research is needed to explore the full potential of Chinese MLs for therapeutic applications.
Standardization of extraction and clinical validation are crucial for developing new mistletoe-based drugs.