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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Reductive Aldol-type Reactions in the Synthesis of Pharmaceuticals
Sofiya Runikhina1, Dmitry Eremin2, Denis Chusov1
1A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 119991, Vavilova St. 28, Moscow, Russian Federation.
Abstract:
The efficient chemo-, regio- and stereoselective formation of saturated carbon-carbon fragment is the critical challenge of organic synthesis; therefore, developing new methods for formation of these bonds is paramount. The rising interest for reductive aldol-type reactions is conditioned by its versatile applications, allowing the efficient formation of carbon-carbon bonds. The review aims to highlight the advantages and disadvantage of reductive aldol-type reactions to total synthesis of pharmaceutical substances in order to summarize knowledge and encourage further investigation of the field.
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