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The use of multi-domain patient reported outcome measures for detecting clinical disease progression in multiple

C A A van 't Hullenaar1, E Coerver2, N F Kalkers3

  • 1Dept. of Neurology, Haaglanden Medisch Centrum, Den Haag, Netherlands; Dept. of Neurology, Amsterdam UMC, location VUmc. Amsterdam, Netherlands.

Multiple Sclerosis and Related Disorders
|August 17, 2021
PubMed
Abstract

Insights

Patient-reported outcome measures (PROMs) correlate well with physical disability in multiple sclerosis (MS). The Guy's Neurological disability scale (GNDS) effectively detects lower limb function changes in progressive MS.

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Patient-Reported Outcomes

Background:

  • Patient-reported outcome measures (PROMs) are increasingly vital, especially with telehealth's rise.
  • Understanding the relationship between PROMs and functional disability in multiple sclerosis (MS) is crucial.

Purpose of the Study:

  • To investigate the correlation between PROMs and functional disability measures in MS patients.
  • To assess the suitability of PROMs for detecting changes in physical function over time.

Main Methods:

  • 248 MS patients were assessed at baseline and over 5 years.
  • Cross-sectional and longitudinal correlations were examined between the Guy's Neurological disability scale (GNDS), MSIS-29 physical, Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT), and timed 25-foot walk (T25FW).

Main Results:

  • Strongest cross-sectional correlations were between GNDS and EDSS, and GNDS and T25FW in progressive MS.
  • Longitudinal correlations were generally poor, except for GNDS leg domain changes and T25FW in progressive MS.
  • Clinically significant EDSS worsening often corresponded to worsening on GNDS and MSIS-physical.

Conclusions:

  • PROMs, particularly the GNDS, show good correlation with physical disability outcomes in MS.
  • The GNDS is suitable for detecting changes in lower limb function in progressive MS.
  • GNDS demonstrates higher agreement with EDSS progression compared to the MSIS-physical.
Keywords:
Disability testsDisease progressionGuy's neurological disability scaleLeg functionMultiple sclerosis impact scalePatient reported outcome measuresProgressive multiple sclerosis

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