Assessing the Efficacy and Outcomes Following Irrigation with Streptokinase Versus Hydrogen Peroxide in Necrotizing...

Percutaneous catheter drainage (PCD's) are prone to blockage because of necrosum. To improve the efficacy of PCD, necrolytic agents have been used. The present study compared the use of Streptokinase with H₂O₂ in saline irrigation.

This is a single-center randomized pilot study (from July 2018 to Dec 2019). Patients with infected pancreatic necrosis not showing response to PCD and saline irrigation were included in the study. Patients received either Streptokinase (Streptokinase group 50,000 IU in 100 ml normal saline) or 3% H₂O₂ (3% H₂O₂ in 100 ml normal saline in 1:10 dilution). Primary endpoints were the need for surgery and mortality while secondary endpoints were hospital stay and complications attributable to necrolytic agents.

There were 30 patients in the study, 15 in each arm. Organ failure was seen in 23 (76.6%), single organ failure was present in 11 (47%), and multi-organ failure in 12 (53%). Bleeding complications (20% in H₂O₂ vs 6.6% in Streptokinase), need for surgery (73% in H₂O₂ vs 33.3% in Streptokinase) and mortality (60% in H₂O₂ vs 33% in Streptokinase) were higher in H₂O₂ group but the difference was not significant statistically. Post-irrigation hospital stay was lesser in the Streptokinase group compared to H₂O₂ group but the difference did not reach statistical significance (14.1 ± 7.7 vs 19.2 ± 11.7, p = 0.09) CONCLUSIONS: Streptokinase irrigation led to a trend for reduced need for necrosectomy and mortality. H₂O₂ group had more bleeding complications_. Post-irrigation hospital stay was lesser in Streptokinase group.