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Myeloproliferative disorders: A retrospective cohort study
Rihan Mhmed Ali1, Verra Masoud1
1University of Damascus, Faculty of Medicine, Damascus, Syrian Arab Republic.
Objectives:
This study was aimed to identify the number, shape and distribution of megakaryocytes and to recognize blast cells and its location.Further, to identify presence of fibrosis or increased microvascularity.Also,study correlation between histological findings.
Methods:
A retrospective was conducted between January 2016 to December 2018 at al-mouwasat university hospital. A total of 44 cases of myeloproliferative disorders using H&E and IHC stains were studied.Chi-square test was performed with descriptive statistics.
Results:
Most of our patients were men younger than 75 years of age. 40 was the most prevalent as a median number of megakaryocytes in bone marrow biopsy with normal shape and diffuse pattern, most of biopsies were fibrotic, paratrabecular pattern and absent of hemosiderin deposits that correlate significantly to women patients.Minimal blast cells were more common with diffuse pattern.
Conclusion:
Bone marrow biopsy is a useful investigation in myeloproliferative disorders. Evaluation of megakaryopoiesis, fibrosis, and localization of blasts are possible on a bone marrow biopsy.
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