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Random brick model for drug transport across stratum corneum
1Controlled Drug Delivery Research Center, Rutgers University, College of Pharmacy, Piscataway, NJ 08855-0789.
Journal of Pharmaceutical Sciences
|December 1, 1987
Summary
A new model predicts how drug properties and skin structure affect drug permeation through the stratum corneum. This model accurately interprets experimental data on percutaneous absorption in different skin types.
Area of Science:
- Dermal drug delivery and pharmacokinetics.
- Biophysical modeling of skin barrier function.
Background:
- The stratum corneum is the primary barrier to topical drug absorption.
- Understanding factors influencing drug permeation is crucial for effective topical and transdermal therapies.
Purpose of the Study:
- To develop a predictive model for drug permeation across the stratum corneum.
- To elucidate the impact of stratum corneum physical and chemical properties on drug permeability.
Main Methods:
- Development of a mathematical model for drug permeation.
- Validation of the model using experimental percutaneous absorption data.
Main Results:
- The developed model successfully predicts drug permeation across the stratum corneum.
- The model accounts for variations in skin specimens and their properties.
Conclusions:
- The model provides a valuable tool for predicting drug skin permeability.
- It aids in understanding the complex interplay between drug properties and the skin barrier.