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Updated: Oct 23, 2025

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
Published on: February 22, 2017
Co-infection with Legionella and SARS-CoV-2: a case report
Masaru Shimizu1, Yusuke Chihara2, Sakiko Satake3
1Department of Anesthesia and Perioperative Care, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA. masaru@koto.kpu-m.ac.jp.
Introduction:
We report a case of COVID-19 with Legionella co-infection that was treated successfully.
Case Report:
A 73-year-old man presented to the hospital with symptoms of fatigue that continued for the next 5 days. The patient was receiving docetaxel and prednisolone chemotherapy for prostate cancer. Laboratory findings on admission showed positive urine Legionella antigen test and SARS-CoV-2 test. He was administered antiviral and antibacterial agents, and a corticosteroid. Pneumonia exacerbated on day 2 of hospitalization. The patient underwent tracheal intubation and began receiving multidisciplinary care. On day 8 of hospitalization, his oxygenation improved, and the patient was extubated. He discharged on day 27 of hospitalization.
Conclusions:
The patient had a favorable outcome with early diagnosis and early treatment of both diseases. Patients with severe COVID-19 disease need to be evaluated for co-infection. Further, early diagnosis and early treatment of the microbial bacteria causing the co-infection are important.
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