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Updated: Oct 23, 2025

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The role of exosomes derived miRNAs in cancer

Shahid Hussain1, Syeda Eeman Zahra Bokhari1, Xing Xing Fan2

  • 1Department of Biosciences, Capital University of Science and Technology, Islamabad, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|August 19, 2021
PubMed

Insights

Circulatory exosomes transport micro ribonucleic acid (miRNA), crucial regulators in cancer development and drug resistance. Further research is needed for their clinical application as diagnostic biomarkers.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Exosomes are nano-sized vesicles involved in intercellular communication.
  • Micro ribonucleic acid (miRNA) is a key regulator of gene expression.
  • Circulatory miRNAs within exosomes play roles in normal and diseased states.

Purpose of the Study:

  • To summarize the role of exosome-carried miRNA in cancer.
  • To highlight miRNA's involvement in cancer progression and resistance.
  • To explore the potential of exosomal miRNA as cancer biomarkers.

Main Methods:

  • Literature review of studies on exosomal miRNA in cancer.
  • Analysis of miRNA's functions in gene regulation, cell proliferation, apoptosis, and drug resistance.
  • Synthesis of current knowledge on miRNA's role in metastasis and cancer resistance.

Main Results:

  • Exosomal miRNAs are implicated in cancer development and progression.
  • miRNAs regulate genes involved in drug resistance, cell proliferation, cell cycle, and apoptosis.
  • Exosomal miRNAs show potential as diagnostic biomarkers for cancer, metastasis, and resistance.

Conclusions:

  • Exosomal miRNAs are significant regulators in cancer biology.
  • Understanding exosomal miRNA functions is vital for cancer treatment strategies.
  • Further investigation is required to translate exosomal miRNA research into clinical applications.
Keywords:
Exosomes, miRNAs, Cancer.

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