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Published on: February 12, 2017
Surgical Outcomes in Patients With Centrally Located Non-small Cell Lung Cancer
Takuma Tsukioka1, Nobuhiro Izumi2, Hiroaki Komatsu2
1Department of Thoracic Surgery, Osaka City University, Osaka, Japan m1156870@med.osaka-cu.ac.jp.
Background/Aim:
Identification of prognostic factors is helpful in selecting optimal treatment for centrally-located non-small cell lung cancer (NSCLC). This study aimed to detect prognostic factors in patients with centrally-located NSCLC.
Patients And Methods:
NSCLCs in the hilar area requiring pneumonectomy or sleeve lobectomy for complete removal are defined as centrally-located NSCLCs. We retrospectively investigated the clinical courses of 45 patients with such lesions.
Results:
Sleeve lobectomies were performed on 33 patients and pneumonectomies on 12. Three and five-year survival rates were 72% and 62%, respectively. Presence of comorbidities (p=0.013), severe symptoms (p=0.001), high white cell count (p=0.001), and pathological T3-4 stage (p=0.004) were identified as independent predictors of poor prognosis. Operative procedures did not correlate with outcomes (p=0.722).
Conclusion:
Presence of comorbidities, severe symptoms, high white cell counts, and pathological T stage are independent predictors of poor prognosis. These data can contribute in selecting appropriate treatments for such lesions.
