Related Experiment Video
Updated: Oct 23, 2025

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
Published on: July 11, 2016
Systems biology under heat stress in Indian cattle
Raja Ishaq Nabi Khan1, Amit Ranjan Sahu1, Waseem Akram Malla1
1Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Bareilly, India.
Abstract:
Transcriptome profiling of Vrindavani and Tharparkar cattle (n = 5 each) revealed that more numbers of genes were dysregulated in Vrindavani than in Tharparkar. A contrast in gene expression was observed with 18.9 % of upregulated genes in Vrindavani downregulated in Tharparkar and 17.8% upregulated genes in Tharparkar downregulated in Vrindavani. Functional annotation of genes differentially expressed in Tharparkar and Vrindavani revealed that the systems biology in Tharparkar is moving towards counteracting the effects due to heat stress. Unlike Vrindavani, Tharparkar is not only endowed with higher expression of the scavengers (UBE2G1, UBE2S, and UBE2H) of misfolded proteins but also with protectors (VCP, Serp1, and CALR) of naïve unfolded proteins. Further, higher expression of the antioxidants in Tharparkar enables it to cope up with higher levels of free radicals generated as a result of heat stress. In this study, we found relevant genes dysregulated in Tharparkar in the direction that can counter heat stress.
Related Concept Videos
Responses to Heat and Cold Stress
Other Stress Responses in Bacteria
Responses to Salt Stress
Adaptations that Reduce Water Loss
Thermal Stress
Stress Response System
Alarm stage
In the alarm stage, the body's...

