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No Spread of SARS-CoV-2 From Infected Symptomatic Children to Parents: A Prospective Cohort Study in a Controlled

Francesco Nunziata1, Marco Poeta1, Edoardo Vassallo1

  • 1Department of Translational Medical Sciences, Section of Paediatrics, University of Naples Federico II, Naples, Italy.

Frontiers in Pediatrics
|August 20, 2021
PubMed

Insights

In a study of 12 child-parent pairs, infected children did not transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to their caregivers. This suggests limited child-to-adult transmission, offering reassurance for school reopenings.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Transmission rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from children to adults remain unclear.
  • Controlled studies are lacking to accurately assess this transmission dynamic.

Purpose of the Study:

  • To investigate the occurrence of SARS-CoV-2 transmission from hospitalized children to their caregivers.
  • To assess the risk of SARS-CoV-2 spread within child-parent pairs under close contact conditions.

Main Methods:

  • A cohort study involving 12 child-parent pairs hospitalized in isolation rooms.
  • Caregivers and children maintained close contact throughout the hospitalization period.
  • Swab and serology testing were performed on caregivers at admission.

Main Results:

  • 136 children tested positive for SARS-CoV-2 during hospitalization.
  • 12 caregivers (8.8%) were negative for SARS-CoV-2 at admission despite close contact with infected children.
  • No SARS-CoV-2 transmission was observed from infected children to their negative caregivers during prolonged close contact.

Conclusions:

  • Hospitalized children did not transmit SARS-CoV-2 to their caregivers, even with prolonged close contact.
  • This suggests potential resistance in adults or limited child-to-adult transmission.
  • Findings may support school reopening decisions and future variant studies.

Keywords:
COVID-19caregiverchildrensevere acute respiratory syndrome coronavirus 2spreading infection

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