Related Experiment Video
Updated: Oct 23, 2025

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
Gut Microbiota and Atherosclerosis-Focusing on the Plaque Stability
Xinyi Shen1, Lihua Li2, Zhen Sun1
1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Abstract:
Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.
Related Concept Videos
Atherosclerosis I: Introduction
Inflammation
Atherosclerosis III: Management
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease I: Introduction
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

