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Published on: November 29, 2018
Relationship between semen regurgitation and pregnancy rates with intrauterine insemination
LaTasha B Craig1, Sushila Arya1, Heather R Burks1
1Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Objective:
To evaluate the relationship between semen regurgitation and intrauterine insemination (IUI) outcomes. We hypothesized that clinical pregnancy rates and live birth rates would be reduced when regurgitation occurred.
Design:
Retrospective cohort study.
Setting:
A university-based reproductive endocrinology and infertility clinic.
Patient(S):
Retrospective review of 1,957 IUI cycles performed on 660 patients between July 2007 and May 2012.
Intervention(S):
None.
Main Outcome Measure(S):
The primary outcome was live birth. Secondary outcomes were positive serum pregnancy result and clinical pregnancy. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a cluster-weighted generalized estimating equations method to estimate modified Poisson regression models with robust standard errors to account for multiple IUI cycles in the same patient.
Result(S):
Live birth rates were similar in IUI cycles with and without regurgitation (6.3% vs. 6.8%, respectively, RR = 0.82, 95% CI [0.53-1.26]). Clinical pregnancy rates in the presence or absence of regurgitation were 10.5% vs. 10.0% (RR = 0.99, 95% CI [0.73-1.35]). Positive serum pregnancy tests after IUI did not differ by regurgitation status (15.0% vs. 15.4%, RR = 0.97, 95% CI [0.75-1.24]). Results were unchanged when adjusted for covariates (age, race and ethnicity, body mass index, duration of infertility, medication, infertility diagnosis, total motile count, and method of sperm preparation).
Conclusion(S):
The presence of regurgitation during the IUI procedure is not related to pregnancy outcome.
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