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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
Published on: May 2, 2018
Comparative genomics of Enterobacter cloacae complex before and after acquired clinical resistance to
Fiona Senchyna1, Fiona B Tamburini2, Kanagavel Murugesan1
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Abstract:
Resistance to Ceftazidime-Avibactam in Enterobacter cloacae is poorly understood. Whole genome sequencing identified 6 variants in isolates collected from a patient before and after acquiring Ceftazidime-Avibactam resistance. This included a Phe396Leu mutation in acrB, a component of the AcrAB-TolC efflux pump, possibly mediating enhanced efflux of Ceftazidime and/ or Avibactam.
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