Risk factors for hypertensive phase after Ahmed glaucoma valve implantation
Related Experiment Video
Updated: Oct 23, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
Onur Özalp1, Serdar İlgüy2, Eray Atalay3
1Ophthalmology Clinic, Devrek State Hospital, Zonguldak, Turkey.
Insights
Half of patients experienced a hypertensive phase (HP) after Ahmed glaucoma valve (AGV) implantation. Higher preoperative intraocular pressure and younger age were key risk factors for developing HP.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Intraocular Pressure Management
Background:
- Ahmed glaucoma valve (AGV) implantation is a surgical option for refractory glaucoma.
- Postoperative hypertensive phase (HP) is a potential complication following AGV implantation, necessitating careful monitoring.
Purpose of the Study:
- To identify risk factors and clinical characteristics associated with the hypertensive phase (HP) after Ahmed glaucoma valve (AGV) implantation.
- To analyze the incidence and resolution patterns of HP in patients undergoing AGV surgery.
Main Methods:
- Retrospective study of 60 eyes from 57 patients with at least 1-year follow-up after AGV implantation.
- Hypertensive phase defined as intraocular pressure (IOP) > 21 mmHg within the first 3 months post-surgery.
- Logistic regression analysis employed to determine independent risk factors for HP development.
Main Results:
- Hypertensive phase (HP) occurred in 51.7% of eyes, with an average peak IOP of 27.6 mmHg.
- HP resolved in 87.1% of affected eyes by the 3-month postoperative visit.
- Independent risk factors for HP included preoperative IOP > 30 mmHg and younger age (≤64 years). Traumatic glaucoma showed the highest HP rate (83.3%).
Conclusions:
- The hypertensive phase (HP) is a common occurrence after Ahmed glaucoma valve (AGV) implantation, affecting approximately half of the patients.
- Elevated preoperative intraocular pressure and younger patient age are significant risk factors for developing HP.
- While most cases of HP resolve by three months, affected eyes may require more intensive IOP-lowering management.
Purpose:
To investigate the risk factors and the clinical characteristics of the hypertensive phase (HP) after Ahmed glaucoma valve (AGV) implantation.
Methods:
This retrospective study included 60 eyes of 57 patients who underwent AGV implantation and with at least 1-year follow-up. HP was defined as intraocular pressure (IOP) > 21 mmHg in the first 3 months after the surgery. Independent samples t-test and Chi-square test were used to compare differences in patients with the HP and the non-HP groups. Univariable and multivariable logistic regression analyses were used to determine the risk factors for the development of the HP. Statistical significance was assumed at p < 0.05 level.
Results:
HP was observed in 31 eyes (51.7%) with an average peak IOP of 27.6 ± 4.5 mmHg (range 22-40 mmHg). The resolution of HP was noted in 27 eyes (87.1%) at the 3rd month postoperative visit. The number of glaucoma medications at the last postoperative visit and IOP values from 1 month to 1 year were significantly higher in the HP group (all p < 0.05). Patients with traumatic glaucoma showed the highest rate (83.3%) of HP development. In the multivariable analysis, a preoperative IOP > 30 mmHg (p = 0.03, OR:5.82; reference: ≤ 25 mmHg) and younger age (41-64 years, p = 0.02, OR:8.49; ≤ 40 years, p = 0.001, OR:19.62; reference: ≥ 65 years) were independently associated with the occurrence of HP.
Conclusion:
Hypertensive phase was observed in half of the patients undergoing AGV implantation. A higher mean preoperative IOP and younger age were risk factors for HP development. Although the majority resolved at the 3-month visit, eyes with HP had higher mean IOPs and required more IOP lowering medications.
Related Concept Videos
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Aneurysm III: Interprofessional Care
Aortic Regurgitation I: Introduction
Hypertension II: Pathophysiology

