Related Experiment Video
Updated: Oct 23, 2025
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Initial Experiences with the MitraClip G4: Review of the Novel Device Features
Christopher W Ives1, Shane P Prejean2, Panos N Vardas3
1996842865 Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, AL, USA.
Objective:
Percutaneous edge-to-edge mitral valve repair is an evolving procedure with increasing indications for use. The MitraClip™ G4 is the newest device with 4 device options, each with distinct characteristics. While the NTR and XTR clips have been in use, the G4 adds 2 new wider clips with additional features, the NTW and XTW.
Methods:
We reviewed 26 cases employing the MitraClip G4 at our institution from November 2019 to March 2020.
Results:
The NTR, XTR, NTW, and XTW clips were used in 3 (11.5%), 0 (0.0%), 16 (61.5%), and 11 (42.3%) cases, respectively. Median mitral regurgitation grade was reduced from 4+ to 1+, though 7 (27%) cases had 2+ residual mitral regurgitation.
Conclusions:
The new G4 device includes simplified instructions for use, the option of a wider clip, controlled gripper actuation, and potential left atrial pressure monitoring. The newest MitraClip G4 device allows for potential improved treatment options for patients with mitral regurgitation.
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