Intestinal and hepatic changes following superior mesenteric artery occlusion shock in dogs

The protective role of the liver in haemorrhagic shock was strongly suggested. However, hepatic changes in other forms of shock has not been elucidate the purpose of present work were to investigate. The morphological and histochemical changes of the liver in SMAO shock were observed. In six mongrel dogs severe SMAO shock was produced by occlusion of superior mesenteric artery for 4 hours and experiment was terminated when agony of animals began. Six healthy dogs severed as control group. In SMAO shock the microscopic findings supposed severe necrotic changes in intestinal epithelium. Simultaneously distinct degenerative changes in hepatic cells with vacuolization of enzymic cytoplasm. The reaction to acid phosphatase was more intensive and partially diffuse. The staining reaction alkaline phosphatase, succinic dehydrogenase, and lactic dehydrogenase varied from strongly positive to negative. Different changes of p.a.S. reaction and protein and groups SH and groups NH were observed suggesting the damage hepatocytes. The results of this study suggest the severe disturbances in hepatic morphology and function following the SMAO shock. The pathogenesis of this changes is discussion.