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Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
Published on: February 17, 2013
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Dynamic perfusion analysis in acute ischemic stroke: A comparative study of two different softwares
Cornelius Krusche1, Carolina Rio Bartulos1, Mazen Abu-Mugheisib2
1Institut für Röntgendiagnostik und Nuklearmedizin, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer str. 90, Braunschweig, Germany.
Clinical Hemorheology and Microcirculation
|August 23, 2021
Summary
Two software tools for evaluating acute ischemic stroke patients before thrombectomy showed good agreement. While Olea Sphere predicted smaller infarct core volumes than Syngo CT Neuro Perfusion, both are valuable for diagnostic support.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Rapid clinical decisions in stroke care necessitate reliable automated diagnostic support software.
- Perfusion computed tomography (CT) and its data evaluation are crucial for selecting recanalization therapy in acute ischemic stroke.
- Evaluating software performance is key to optimizing acute stroke treatment selection.
Purpose of the Study:
- To compare the performance of commercially available software for evaluating stroke patients.
- Specifically, this study compared Olea Sphere (OlS) and Syngo CT Neuro Perfusion (Sy) software.
- The study also assessed the electronic Alberta Stroke Program Early Computed Tomography Score (e-ASPECTS) against an expert radiologist.
Main Methods:
- Retrospective analysis of 43 middle cerebral artery territory stroke patient datasets.
- Comparison of OlS and Sy software for ischemic core, penumbra (Tmax), and mismatch parameters.
- Statistical analysis included descriptive statistics, Spearman's correlation, and Bland-Altman agreement analysis.
Main Results:
- The e-ASPECTS software demonstrated high agreement with expert radiologist assessments.
- Both OlS and Sy software showed good agreement for core and penumbra parameters, with well-correlated values.
- A significant difference was observed, with OlS predicting smaller infarct core volumes compared to Sy.
Conclusions:
- Despite variations in absolute values, both Olea Sphere and Syngo CT Neuro Perfusion software exhibit good inter-tool agreement.
- These findings support the utility of automated software in acute stroke evaluation and treatment planning.
