[Basic Research on Comparative Evaluation of Calculated Dose Distribution Using Monte Carlo Algorithm-equipped...

The purpose was to study comparative evaluation of calculated dose distribution by X-ray Voxel Monte Carlo (XVMC) for dose calculation in Acuros XB (AXB). The dose commissioning and head and neck volumetric modulated arc therapy (VMAT) clinical cases were compared for AXB in Eclipse and XVMC in Monaco.

For TrueBeam at 6 MV, we compared the dose commissioning for simple rectangle, heterogeneity correction, and multileaf collimator (MLC) characteristics. 15 clinical cases were compared for computation times, calculation accuracy, dose-volume histogram (DVH), and 3D-γ analysis (γ 3%/2 mm).

There was no difference between the calculated values of jaw field, the measurement errors of both were within± 1%, and the dose profiles of water, bone, and lung equivalent slab phantoms were in good agreement. There was no difference in transmission, tongue and groove effect, and there was a difference of less than 10% in leaf-end transmission. In clinical cases, the computation time of XVMC was a half time that of AXB, the average values of the dose difference between the two dose calculations were -1.17±2.14%, and there was no difference in measurement error (AXB: -0.73±0.79%, XVMC: -0.07±1.21%). In DVH, max doses of XVMC were about 3% higher in planning target volume (PTV) and gross tumor volume (GTV), but the pass rate of 3D-γ analysis was overall 95.11±2.59%, which was in good agreement.

Both dose calculation algorithms were equivalent, suggesting that Monaco XVMC is a verification method with a high accuracy for comparative evaluation of calculated dose distribution.