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Published on: December 19, 2020
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Pathological Features in 100 Deceased Patients With COVID-19 in Correlation With Clinical and Laboratory Data
L M Mikhaleva1, A L Cherniaev1, M V Samsonova1
1Research Institute of Human Morphology, Moscow, Russia.
Pathology Oncology Research : POR
|August 23, 2021
Summary
Autopsies reveal widespread coagulopathy and diffuse alveolar damage as key factors in COVID-19 mortality. Extrapulmonary effects on the liver and spleen are also significant in understanding fatal outcomes from SARS-CoV-2 infection.
Area of Science:
- Pathology
- Infectious Diseases
- Forensic Medicine
Background:
- COVID-19 autopsies face limitations due to safety measures.
- Clinical data may not align with post-mortem findings.
- Understanding COVID-19 mortality mechanisms is crucial.
Purpose of the Study:
- Identify pathognomonic factors in COVID-19 mortality.
- Correlate clinical and autopsy findings.
- Analyze 100 full-body autopsies of COVID-19 deceased patients.
Main Methods:
- Conducted 100 full-body autopsies following safety protocols.
- Evaluated macroscopic and microscopic pathologies.
- Assessed clinical and laboratory findings.
Main Results:
- Widespread coagulopathic changes observed.
- Diffuse alveolar damage is pathognomonic for COVID-19 pneumonia, especially in younger patients.
- Extrapulmonary pathology affects liver and spleen; intravascular thrombosis and septic shock are common.
Conclusions:
- Pathological findings offer insight into SARS-CoV-2 lethality.
- COVID-19 severity may be influenced by genetic or epigenetic factors.
- No obvious bias in severity, but individual variability exists.
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