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Updated: Oct 23, 2025

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Basic Pan-Cancer Analysis of the Carcinogenic Effects of Cyclin-Dependent Kinase 4 (CDK4) in Human Surface Tumors

Jingping Wu1, Tinghan Deng2, Yuanen Huang2

  • 1Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Journal of Healthcare Engineering
|August 23, 2021
PubMed

Insights

This study explored the role of CDK4 in various human skin tumors. High CDK4 expression was linked to poorer cancer prognosis, suggesting its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The role of Cyclin-Dependent Kinase 4 (CDK4) in cancer is known, but a comprehensive pan-cancer analysis in human skin tumors is lacking.
  • Previous research suggests potential links between CDK4 and carcinogenesis, necessitating further investigation.

Purpose of the Study:

  • To conduct a pan-cancer analysis of CDK4 gene expression and its correlation with patient prognosis across 33 human tumors.
  • To investigate the oncogenic effects of CDK4 in human skin tumors, including melanoma and lung adenocarcinoma.

Main Methods:

  • Utilized datasets from Gene Expression Omnibus (GEO) and Cancer Genome Atlas (CGA) for pan-cancer analysis.
  • Examined CDK4 expression levels, patient prognosis, and specific molecular alterations (e.g., r24l/C/h/s phosphorylation) in various tumor types.
  • Assessed fibroblast infiltration associated with CDK4 in specific skin cancers.

Main Results:

  • CDK4 was found to be highly expressed in the majority of analyzed cancers.
  • Elevated CDK4 expression significantly correlated with poorer patient prognosis across multiple cancer types.
  • Increased r24l/C/h/s phosphorylation and fibroblast infiltration were observed in CDK4-associated skin cancers like melanoma and head and neck tumors.

Conclusions:

  • This pan-cancer study provides preliminary evidence for the oncogenic role of CDK4 in diverse human skin tumors.
  • CDK4's high expression and association with poor prognosis highlight its potential as a therapeutic target in skin cancer treatment.

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