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Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases
Sizhuo Liu1, Tinghan Deng1, Hongbin Cheng2
1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
Pharmaceutics
|June 27, 2025
Summary
Transdermal drug delivery systems offer a promising alternative for inflammatory skin diseases, improving treatment efficacy and patient experience. These advanced methods enhance drug penetration and sustained release, addressing limitations of traditional therapies.
Area of Science:
- Dermatology
- Pharmaceutics
- Biomedical Engineering
Background:
- Inflammatory skin diseases cause significant pain and tissue damage.
- Current treatments like oral drugs and injections have limitations.
- Transdermal drug delivery systems (TDDSs) are gaining interest for improved therapeutic options.
Purpose of the Study:
- To review the skin barrier and clinically adopted TDDSs.
- To highlight emerging microneedle and nanocarrier strategies.
- To synthesize evidence on TDDSs for atopic dermatitis, psoriasis, and acne.
Main Methods:
- Comprehensive review of the skin barrier.
- Critical summary of established TDDSs (sonophoresis, iontophoresis, etc.).
- Emphasis on novel microneedle and nanocarrier systems.
Main Results:
- TDDSs facilitate sustained drug release and reduce dosing frequency.
- Microneedle and nanocarrier technologies show advanced transdermal delivery potential.
- Evidence supports TDDS application for treating atopic dermatitis, psoriasis, and acne.
Conclusions:
- TDDSs offer a more effective and targeted approach to managing inflammatory skin diseases.
- These systems present advantages over traditional methods, with ongoing advancements.
- TDDSs hold potential for safer and more efficient treatment strategies.
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