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Updated: Oct 23, 2025
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High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
Published on: August 12, 2019
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DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges
Adrián Gironda-Martínez1, Etienne J Donckele1, Florent Samain1
1Philochem AG, Libernstrasse 3, CH-8112 Otelfingen, Switzerland.
ACS Pharmacology & Translational Science
|August 23, 2021
Summary
DNA-encoded chemical libraries (DELs) enable the discovery of potent small-molecule ligands for drug development. This technology uses DNA tags for molecule identification and has led to compounds entering clinical trials.
Area of Science:
- Medicinal Chemistry
- Chemical Biology
- Drug Discovery
Background:
- DNA-encoded chemical libraries (DELs) are powerful platforms for identifying small-molecule ligands.
- Each molecule in a DEL is tagged with a unique DNA barcode for identification.
- Advances in DNA-compatible chemistry, selection, sequencing, and analysis have enabled large-scale DEL screening.
Purpose of the Study:
- To provide an overview of DEL generation and screening approaches.
- To highlight recent successes and case studies in DEL-based drug discovery.
- To discuss future challenges and opportunities for DEL technology.
Main Methods:
- Construction and screening of large DEL molecular repertoires.
- Utilizing DNA-compatible chemical reactions.
- Employing next-generation sequencing and data analysis for ligand identification.
Main Results:
- Discovery of highly potent small-molecule ligands from DEL screening.
- Identification of ligands that have advanced to clinical trials.
- Demonstration of DEL technology's capability in identifying novel therapeutic candidates.
Conclusions:
- DEL technology is a proven and evolving platform for drug discovery.
- Continued advancements are expected to further enhance DEL capabilities.
- DELs offer significant potential for identifying future therapeutics.
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