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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Frozen and cold-stored platelets: reconsidered platelet products
Teresa Jimenez-Marco1,2, Azucena Castrillo3, Fernando Hierro-Riu4
1Fundació Banc De Sang I Teixits De Les Illes Balears, Majorca, Spain.
Platelets
|August 23, 2021
Summary
Storing platelets at cold or frozen temperatures offers significant advantages over current room temperature methods. This approach reduces bacterial contamination and extends shelf-life, improving availability for patients needing rapid hemostatic response.
Area of Science:
- Transfusion Medicine
- Hematology
- Biotechnology
Background:
- Current platelet storage at room temperature (20-24°C) limits shelf-life to 5-7 days due to bacterial growth.
- This short storage period leads to high wastage rates and logistical challenges, particularly for remote areas.
Purpose of the Study:
- To re-evaluate and characterize the potential of platelet cryopreservation and refrigeration.
- To assess the feasibility of utilizing these storage methods to improve platelet product availability and reduce waste.
Main Methods:
- Review of recent research efforts characterizing cold and cryopreserved platelets.
- Analysis of the pro-coagulant profile and hemostatic response of stored platelets.
Main Results:
- Recent studies indicate cryopreserved and cold-stored platelets exhibit a pro-coagulant profile.
- This profile suggests potential for rapid hemostatic response in bleeding patients.
Conclusions:
- Refrigerated and cryopreserved platelets show promise for extending shelf-life and reducing bacterial risk.
- Blood banks should consider split inventories of room temperature, cold-stored, and cryopreserved platelets.
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