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Gram-Negative Bacteria Harboring Multiple Carbapenemase Genes, United States, 2012-2019

D Cal Ham, Garrett Mahon, Sandeep K Bhaurla

    Emerging Infectious Diseases
    |August 23, 2021
    PubMed

    Insights

    Multiple carbapenemase genes in organisms are rising. The Centers for Disease Control and Prevention identified 151 isolates from 100 patients in the US between 2012-2019, with travel and transplantation as key risk factors.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Reports of organisms with multiple carbapenemase genes have increased globally since 2010.
    • Carbapenemase-producing Enterobacteriaceae (CPE) pose a significant public health threat due to limited treatment options.

    Purpose of the Study:

    • To document the incidence and characteristics of isolates harboring multiple carbapenemase genes in the United States.
    • To identify potential risk factors associated with these infections.

    Main Methods:

    • Retrospective analysis of data collected by the Centers for Disease Control and Prevention (CDC) from October 2012 to April 2019.
    • Documentation of the number of isolates and patients identified with multiple carbapenemase genes.
    • Analysis of patient data to identify associated risk factors.

    Main Results:

    • A total of 151 isolates from 100 patients with multiple carbapenemase genes were identified in the US.
    • The study period was from October 2012 to April 2019.
    • Identified risk factors included recent international travel, international inpatient healthcare, and solid organ or bone marrow transplantation.

    Conclusions:

    • The United States has seen an increase in organisms carrying multiple carbapenemase genes.
    • International travel, healthcare exposure abroad, and transplantation are significant risk factors for acquiring these multidrug-resistant organisms.
    • Enhanced surveillance and infection control measures are crucial to mitigate the spread of carbapenemase-producing organisms.
    Keywords:
    AMRAcinetobacter baumanniiEnterobacteriaceaePseudomonasUnited Statesantimicrobial resistancecarbapenem-resistant Enterobacteralescarbapenemasecarbapenemsdrug resistanceresistance genes

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