Ionic liquids as a useful tool for tailoring active pharmaceutical ingredients

Area of Science:

• Pharmaceutical Science
• Materials Science
• Biotechnology

Background:

• Ionic liquids (ILs) are increasingly utilized in biomedical and pharmaceutical applications.
• Optimizing active pharmaceutical ingredient (API) properties using ILs technology is a growing research area.

Purpose of the Study:

• To review the current status of API-ILs in biomedical and pharmaceutical fields.
• To cover the rational design, preparation, characterization, and formulation compatibility of API-ILs.
• To discuss the future prospects of API-ILs for advanced drug delivery.

Main Methods:

• Review of existing literature on API-ILs.
• Analysis of studies focusing on the design and preparation of API-ILs.
• Evaluation of research on the physicochemical improvements and formulation applications of API-ILs.

Main Results:

• Converting APIs into ILs (API-ILs) can eliminate polymorphism, tailor solubility, and enhance thermal stability.
• API-ILs demonstrate potential for controlled drug release, improved permeability, and modulated cytotoxicity.
• API-ILs are versatile and can be incorporated into various formulations like solutions, emulsions, tablets, and nanoparticles.

Conclusions:

• API-ILs represent a promising approach for improving drug delivery and overcoming limitations of conventional APIs.
• Further research into API-ILs will likely lead to novel pharmaceutical formulations and therapeutic strategies.
• The unique properties of API-ILs offer significant advantages for diverse biomedical applications.