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Updated: Oct 23, 2025

Preparing an Isotopically Pure 229Th Ion Beam for Studies of 229mTh
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Ytterbium-175 half-life determination.

M Teresa Durán1, Frédéric Juget1, Youcef Nedjadi1

  • 1Institute of Radiation Physics, Lausanne, Switzerland.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|August 23, 2021
PubMed
Summary

The half-life of the radionuclide Ytterbium-175 (175Yb) was accurately redetermined to be 4.1615 days. This finding is crucial for the metrological standardization of radiopharmaceuticals used in therapy.

Keywords:
(175)YbDigital electronics.Half-lifeIonization chamberStandardization

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Area of Science:

  • Nuclear Physics
  • Radiopharmaceutical Science

Background:

  • Ytterbium-175 (175Yb) is a radionuclide with therapeutic radiopharmaceutical potential.
  • Existing nuclear data for 175Yb, including its half-life, are outdated and insufficient for metrological purposes.

Purpose of the Study:

  • To redetermine the half-life of 175Yb with high accuracy.
  • To provide reliable data for the metrological standardization of 175Yb.

Main Methods:

  • Neutron capture on 174Yb to generate 175Yb.
  • Three independent measurement techniques: reference ionization chamber, digital CeBr3 gamma-ray detector, and analog CeBr3 detector with SCA.
  • Detailed uncertainty calculations.

Main Results:

  • The redetermined half-life of 175Yb is 4.1615(30) days.
  • This value shows a 0.56% relative deviation from the previously accepted ENSDF 2004 value.

Conclusions:

  • The new half-life value provides an accurate basis for 175Yb standardization.
  • This research supports the development and application of 175Yb in therapeutic radiopharmaceuticals.