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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

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The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
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Exocrine Glands: Types of Secretions01:13

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Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
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Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

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Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine...
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Accessory Organs01:31

Accessory Organs

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Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
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Oral Cavity01:11

Oral Cavity

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The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
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Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

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Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
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Related Experiment Video

Updated: Oct 23, 2025

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Salivary gland: A budding genius.

Oscar Cazares1, Ameera S Haque1, Ophir D Klein2

  • 1Program in Craniofacial Biology and Division of Craniofacial Anomalies, Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.

Developmental Cell
|August 24, 2021
PubMed
Summary

Mouse salivary gland branching, essential for development, depends on the interaction between epithelial cells and their surrounding extracellular matrix. This balance is crucial for proper bud formation and tissue organization.

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Last Updated: Oct 23, 2025

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Tissue Engineering

Background:

  • Salivary gland development involves complex branching morphogenesis.
  • Branching occurs through processes like budding and clefting.
  • The extracellular matrix plays a critical role in tissue development.

Purpose of the Study:

  • To investigate the mechanisms underlying salivary gland budding.
  • To elucidate the interplay between epithelial cells and the extracellular matrix during development.
  • To understand the cellular and molecular regulation of branching morphogenesis.

Main Methods:

  • Utilized mouse models for studying salivary gland development.
  • Employed advanced imaging techniques to visualize cellular and matrix interactions.
  • Analyzed the molecular components and mechanical properties of the extracellular matrix.

Main Results:

  • Demonstrated that salivary gland budding is critically dependent on the epithelial-extracellular matrix interaction.
  • Identified specific components of the extracellular matrix that regulate bud formation.
  • Showed that disruptions in this interplay lead to aberrant branching patterns.

Conclusions:

  • The delicate balance between epithelial cells and the extracellular matrix is essential for normal salivary gland budding.
  • Understanding this interaction provides insights into developmental processes and potential therapeutic targets for salivary gland disorders.