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Predictive Factors for Target Organ Injuries in Hypertensive Individuals

Manoel Paz Landim1, Luciana Neves Cosenso-Martin1, Aleandra Polegati Santos1

  • 1Internal Medicine Department, State Medical School at Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto, Sao Paulo, Brazil.

Integrated Blood Pressure Control
|August 25, 2021
PubMed

Insights

Hypertension management significantly reduced blood pressure, but only nocturnal blood pressure predicted left ventricular hypertrophy. Other target organ damage factors include age, diabetes, and lipid levels.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Systemic arterial hypertension is linked to target organ damage (TOD) and cardiovascular risk factors.
  • Ambulatory blood pressure monitoring (ABPM) is crucial for managing hypertension and assessing TOD risk.

Purpose of the Study:

  • To investigate the relationship between blood pressure (BP) and clinical/biochemical markers in hypertensive patients' TOD development.
  • To assess the impact of ABPM on TOD progression over a 13-year follow-up.

Main Methods:

  • Retrospective cohort study of 162 hypertensive patients.
  • Investigated left ventricular hypertrophy (LVH), microalbuminuria, coronary artery disease (CAD), and stroke as TODs.
  • Utilized ABPM, echocardiogram, electrocardiogram, and biochemical tests for assessment.

Main Results:

  • While ABPM showed BP reduction, it didn't correlate with microalbuminuria, stroke, or CAD.
  • Left ventricular hypertrophy (LVH) correlated with sleep BP ≥120/70 mmHg (P=0.044).
  • Frequent TODs included LVH (29.6%), microalbuminuria (26.5%), CAD (19.8%), and stroke (17.3%).

Conclusions:

  • Predictive factors for TOD are age, microalbuminuria, diabetes, HDL-c, triglycerides, and carotid disease.
  • Nocturnal BP is correlated with LVH.
  • Effective drug treatments and improved metabolic/BP parameters may explain the lack of association between ABPM and other TODs.
Abstract

Keywords:
albuminuriaambulatory blood pressure monitoringarterial hypertensioncoronary artery diseaseleft ventricular hypertrophystroke

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