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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Epigenetics in prostate cancer: clinical implications.

Vincenza Conteduca1,2, Judy Hess3, Yasutaka Yamada1

  • 1Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Translational Andrology and Urology
|August 25, 2021
PubMed
Summary

Epigenetic alterations drive prostate cancer initiation, progression, and therapy resistance by altering gene expression. Targeting these reversible changes offers new diagnostic and therapeutic strategies for prostate cancer.

Keywords:
DNA methylationEpigeneticshistone methylationneuroendocrine prostate cancerprostate cancer

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Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic alterations (DNA methylation, histone modifications, nucleosome remodeling) are key drivers of prostate cancer.
  • These changes lead to abnormal gene expression, silencing tumor suppressors and activating oncogenes.

Purpose of the Study:

  • To review the role of epigenetics in prostate cancer, focusing on clinical implications.
  • To explore how epigenetic regulators interact with pathways like androgen receptor signaling.
  • To highlight the potential of epigenetic modifications as diagnostic, prognostic, and therapeutic targets.

Main Methods:

  • Literature review of epigenetic mechanisms in prostate cancer.
  • Analysis of the interplay between epigenetic regulators and critical biological pathways.
  • Examination of clinical implications and emerging biomarkers.

Main Results:

  • Epigenetic modifications are crucial in prostate tumor initiation, progression, and therapy resistance.
  • Crosstalk between epigenetic regulators and androgen receptor signaling dynamically controls gene expression.
  • Reversible epigenetic changes offer potential for innovative therapeutic strategies.

Conclusions:

  • Epigenetics plays a fundamental role in prostate cancer development and progression.
  • Epigenetic alterations are emerging as valuable biomarkers and therapeutic targets for advanced prostate cancer.
  • Targeting the epigenome represents a promising frontier for novel prostate cancer treatments.