Nomogram for predicting pathologic complete response after transarterial chemoembolization in patients with
Jian Lin1, Xiaowei Li2, Xiaodong Shi3
1Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Annals of Translational Medicine
|August 25, 2021
Summary
A new nomogram predicts pathologic complete response (PCR) after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). This tool helps identify patients who will benefit most from TACE, guiding further treatment decisions.
Area of Science:
- Hepatobiliary surgery
- Interventional radiology
- Oncology
Background:
- Transarterial chemoembolization (TACE) shows variable outcomes in hepatocellular carcinoma (HCC) treatment.
- Predicting pathologic complete response (PCR) after TACE is crucial for patient management.
Purpose of the Study:
- To develop and validate a predictive nomogram for PCR following TACE in HCC patients.
- To identify key factors influencing TACE treatment response.
Main Methods:
- Analysis of clinicopathologic data from HCC patients undergoing hepatectomy post-TACE.
- Multivariate logistic regression to identify significant predictors of PCR.
- Development and validation of a nomogram incorporating identified predictive factors.
Main Results:
- PCR was observed in 50.4% of the training cohort and 37.5% in the validation cohort.
- Significant predictors of PCR included HBV DNA load, AFP, maximum tumor diameter, TACE sessions, and mRECIST complete response.
- The nomogram demonstrated strong predictive accuracy with concordance indexes of 0.80 and 0.82 in training and validation cohorts, respectively.
Conclusions:
- An easily applicable nomogram effectively predicts post-TACE PCR in HCC.
- This tool can aid in selecting optimal candidates for TACE and guiding subsequent treatment strategies.
