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Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men
J M Streete1, D J Berry, J E Newberry
1Poisons Unit, New Cross Hospital, London, UK.
European Journal of Clinical Pharmacology
|January 1, 1987
Abstract:
The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a study previously performed in young volunteers.