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The Versatile Reaction Chemistry of an Alpha-Boryl Diazo Compound
Yao Liu1, Raimon Puig de la Bellacasa2, Bo Li1
1Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467-3860, United States.
Abstract:
The first α-boryl diazo compound that is capable of engaging in classic synthetic organic diazo reaction chemistry is described. The diazomethyl-1,2-azaborine 1, which is a BN isostere of phenyldiazomethane, is significantly more stable than phenyldiazomethane; its reaction chemistry ranges from C-H activation, O-H activation, [3+2] cycloaddition, and halogenation, to Ru-catalyzed carbonyl olefination. The demonstrated broad range of reactivity of diazomethyl-1,2-azaborine 1 makes it an exceptionally versatile synthetic building block for the 1,2-azaborine heterocyclic motif.
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