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Updated: Oct 23, 2025
![Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63188.jpg&w=3840&q=50)
Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
Published on: April 21, 2023
Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic
Yan Li1, Daniel B Vigneron2, Duan Xu2
1Department of Radiology and Biomedical Imaging, UCSF Radiology, University of California, 185 Berry Street, Ste 350, Box 0946, San Francisco, CA, 94107, USA. yan.li@ucsf.edu.
Abstract:
The ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.

