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Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

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Metal-organic frameworks for diagnosis and therapy of infectious diseases

Christian Rafael Quijia1, Renata Carolina Alves1, Gilmar Hanck-Silva1

  • 1School of Pharmaceutical Sciences, São Paulo State University, UNESP, Araraquara, Brazil.

Critical Reviews in Microbiology
|August 25, 2021
PubMed

Insights

Metal-Organic Frameworks (MOFs) show promise for combating infectious diseases. These materials offer novel antimicrobial agents, drug delivery systems, and diagnostic tools for various pathogens.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Infectious Diseases

Background:

  • Infectious diseases are a major global health concern, driving the search for novel therapeutic and diagnostic strategies.
  • Metal-Organic Frameworks (MOFs), versatile porous materials, present unique properties like high surface area and tunable structures.
  • MOFs offer potential for developing advanced solutions against a wide range of pathogens.

Purpose of the Study:

  • To review the diverse biological applications of MOFs in the context of infectious diseases.
  • To highlight MOFs' roles in diagnosis and treatment of infections caused by bacteria, viruses, fungi, and protozoa.
  • To summarize recent advancements and future directions in MOF-based infectious disease management.

Main Methods:

  • Literature review of studies on MOF applications in infectious disease diagnosis and treatment.
  • Categorization of MOF applications including antimicrobial agents, drug delivery, nanozymes, and phototherapies.
  • Analysis of MOF-based biosensors utilizing electrochemical, fluorometric, and colorimetric detection methods.

Main Results:

  • MOFs demonstrate efficacy as antimicrobial agents and sophisticated drug delivery systems.
  • MOF-based composites, nanozymes, and phototherapies offer innovative treatment modalities.
  • MOF-based biosensors provide sensitive and specific detection of various pathogens.

Conclusions:

  • MOFs represent a promising class of materials for both the treatment and diagnosis of infectious diseases.
  • Their unique properties facilitate the development of advanced antimicrobial strategies and highly sensitive diagnostic tools.
  • Further research into MOFs will likely lead to significant breakthroughs in combating global infectious disease burdens.
Keywords:
MOFsantimicrobial agentsbiosensorsdrug delivery systemsphototherapiestherapeutics

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