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    This study introduces a novel microscope-FTIR spectrometer system and algorithm for identifying neurotransmitters in aqueous solutions. The enhanced system achieves high accuracy in detecting six key neurotransmitters, even in complex mixtures.

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    Area of Science:

    • Analytical Chemistry
    • Spectroscopy
    • Biochemistry

    Background:

    • Accurate detection of neurotransmitters is crucial for understanding neurological processes.
    • Existing methods for neurotransmitter analysis often face limitations in sensitivity and selectivity.
    • Fourier-transform infrared (FTIR) spectroscopy offers potential for molecular identification but requires specialized sample handling.

    Purpose of the Study:

    • To develop and validate a new sensing approach for aqueous samples using microscope-FTIR spectroscopy.
    • To introduce an innovative sample handling system for enhanced microscope-FTIR analysis.
    • To propose a novel algorithm for accurate neurotransmitter identification from IR spectral data.

    Main Methods:

    • Development of a novel sample handling system incorporating a total reflective mirror, heated hydrophobic layer, and microfluidic system.
    • Application of microscope-FTIR spectroscopy for analyzing aqueous samples containing neurotransmitters.
    • Utilizing a newly developed algorithm for analyzing IR spectra and extracting molecular composition.

    Main Results:

    • The new system successfully identified six neurotransmitters (Dopamine hydrochloride, L-Ascorbic acid, Acetylcholine chloride, y-Aminobutyric, Glycine, L-Glutamic acid) in homogeneous and mixture solutions.
    • Estimation ratios for neurotransmitter identification ranged from 75% to 100%, demonstrating high accuracy.
    • The developed algorithm showed high selectivity in distinguishing individual neurotransmitters within complex solutions.

    Conclusions:

    • The integrated microscope-FTIR system with the novel sample handling and analysis algorithm provides a highly effective method for neurotransmitter sensing.
    • This approach offers significant improvements in accuracy and selectivity for identifying neurotransmitters in aqueous environments.
    • The developed technique has potential applications in various fields requiring precise biochemical analysis.