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Effect of acute and chronic liver diseases on the thyroid function in children

Gihan M Bebars1, Madeha A Sayed1, Lamia Hamdy2

  • 1Department of Pediatrics, Faculty of Medicine, Minia University, Minia, 61111, Egypt.

BMC Pediatrics
|August 26, 2021
PubMed

Insights

Thyroid function is altered in children with acute and chronic liver disease. Thyroid hormone levels correlate with disease severity, indicating a significant impact of liver conditions on thyroid health in pediatric patients.

Area of Science:

  • Pediatric Endocrinology
  • Hepatology
  • Thyroidology

Background:

  • Thyroid hormones regulate metabolic rate and liver function.
  • The liver is crucial for thyroid hormone metabolism and endocrine regulation.
  • Liver disease can disrupt normal thyroid hormone homeostasis.

Purpose of the Study:

  • To evaluate thyroid function in children diagnosed with acute and chronic liver diseases.
  • To investigate the relationship between liver disease severity and thyroid function parameters.

Main Methods:

  • 85 children were categorized into four groups: acute hepatitis (AH), chronic liver disease (CLD1, CLD2), and controls.
  • Comprehensive assessments included medical history, physical exams, and laboratory tests (CBC, liver/renal function, viral markers).
  • Thyroid function tests (Free T3, Free T4, TSH) were performed on all participants.

Main Results:

  • Children with AH, CLD1, and CLD2 exhibited lower Free T3 levels.
  • TSH levels were significantly elevated in the CLD2 group (severe chronic liver disease).
  • Correlations were observed between thyroid hormones, liver enzymes (AST), lipid profiles (VLDL, LDL), and coagulation parameters (prothrombin concentration, PT).

Conclusions:

  • Both acute and chronic liver diseases significantly impact thyroid function in children.
  • The degree of thyroid dysfunction is associated with the severity of the liver disease.
Abstract

Keywords:
Acute hepatitisChronic liver diseaseThyroid function tests

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