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"Central command" and sympathetic activation.

A Malliani1

  • 1Institute of Cardiovascular Research, CNR, Milan, Italy.

Functional Neurology
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

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This study analyzes central command and peripheral feedback, revealing a new sympathetic afferent channel. This pathway, involving cardiovascular sympathetic afferent fibers, contributes to sympathetic outflow regulation through excitatory reflexes.

Area of Science:

  • Physiology
  • Neuroscience
  • Cardiovascular Regulation

Background:

  • Sympathetic efferent activity is regulated by central command and peripheral feedback.
  • Recent research identified a novel afferent pathway: cardiovascular sympathetic afferent fibers.

Purpose of the Study:

  • To analyze central command and peripheral feedback mechanisms.
  • To identify the main regulatory components of sympathetic efferent activity.
  • To elucidate the role of the newly described afferent channel.

Main Methods:

  • Conceptual analysis of "central command" and peripheral feedback.
  • Review of literature on cardiovascular sympathetic afferent fibers.
  • Hypothetical modeling of neural regulation of hemodynamic states.

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Main Results:

  • Cardiovascular sympathetic afferent fibers exert a tonic influence on sympathetic outflow.
  • This afferent channel mediates primarily excitatory reflexes with positive feedback.
  • Hemodynamic states are regulated by the interplay of central command and opposing peripheral feedback.

Conclusions:

  • The sympathetic nervous system's regulation is complex, involving central and peripheral inputs.
  • Positive feedback mechanisms from cardiovascular afferents are crucial for sympathetic control.
  • Understanding these interactions is key to comprehending neural regulation of cardiovascular function.