Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

508
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
508
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

559
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
559
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

574
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
574

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Under-ice convective regimes driven by sunlight and sediment temperature control water-ice heat flux.

PNAS nexus·2026
Same author

Unique phenotypic and T cell receptor characteristics of CD8<sup>+</sup> T cells accumulated in the brains of Alzheimer's disease mice.

Scientific reports·2026
Same author

Melting dynamics of freely floating ice in calm waters.

Science advances·2026
Same author

Sandball genesis from raindrops.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

TIM-4 Regulates Allergic Airway Inflammation and Mast Cell Activation by Binding to CD300b.

Journal of asthma and allergy·2025
Same author

Unsteady flows uncover the limits of the stress-optic law.

Nature communications·2025
Same journal

[Let's present at a regional meeting].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Editor's Note].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Notice for Members].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[The Proceedings of the 250th Kyushu Regional Meeting of the Japanese Society of Neurology].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[The Proceedings of the 116th Tohoku Regional Meeting of the Japanese Society of Neurology].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Metagenomic analysis for central nervous system infections: clinical utility and future directions].

Rinsho shinkeigaku = Clinical neurology·2026
See all related articles

Related Experiment Video

Updated: Oct 23, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.4K

[Gut environment and multiple sclerosis].

Sachiko Miyake1, Daisuke Noto1

  • 1Department of Immunology, Juntendo University Graduate School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|August 26, 2021
PubMed
Summary
This summary is machine-generated.

Gut microbiota alterations, or dysbiosis, are linked to multiple sclerosis (MS). Restoring beneficial gut bacteria metabolites like short-chain fatty acids (SCFA) may improve MS and related conditions.

Keywords:
EAEgut microbiotamultiple sclerosisshort chian fatty acid

More Related Videos

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.9K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.0K

Related Experiment Videos

Last Updated: Oct 23, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.4K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.9K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.0K

Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Autoimmune Diseases

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) inflammatory demyelinating disease.
  • T cell-mediated autoimmune processes are implicated in MS pathogenesis.
  • Gut microbiota dysbiosis is increasingly associated with autoimmune diseases, including CNS disorders.

Purpose of the Study:

  • To review recent findings on the interaction between gut microbiota and MS.
  • To explore the role of gut microbiota in the animal model of MS, experimental autoimmune encephalomyelitis (EAE).
  • To discuss the impact of microbial metabolites on CNS autoimmunity.

Main Methods:

  • Review of current literature on gut microbiota and MS.
  • Analysis of studies involving experimental autoimmune encephalomyelitis (EAE) models.
  • Examination of the effects of microbial metabolites on immune cells and CNS function.

Main Results:

  • Gut microbiota dysbiosis, including reduced short-chain fatty acids (SCFA), is observed in MS patients.
  • SCFA administration ameliorates EAE severity by inducing regulatory T cells.
  • Microbial metabolites like SCFA and tryptophan influence glial cell function in the CNS.

Conclusions:

  • Gut microbiota plays a significant role in the pathogenesis and progression of MS.
  • Modulating gut microbiota and its metabolites presents a potential therapeutic strategy for MS.
  • Further research into the gut-brain axis in MS is warranted.