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Myasthenia Gravis-An Analysis of Multimodal Evoked Potentials
Edyta Dziadkowiak1, Marta Waliszewska-Prosół1, Małgorzata Wieczorek2
1Department of Neurology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Introduction:
The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system.
Methods:
A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed.
Results:
In the group of MG patients, the latency of P100 (113.9 ± 13.9; p < 0.0001) VEP, wave III (3.92 ± 0.29; p = 0.015), wave V (5.93 ± 0.32; <0.0001), interlatency III-V (2.00 ± 0.12; p < 0.0001), interlatency I-V (4.20 ± 0.28; p < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower.
Conclusions:
The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients.
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