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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment
Hye One Kim1,2, Seok Young Kang1, Jin Cheol Kim1
1Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, Korea.
Insights
Pediatric psoriasis, a chronic skin disease, has distinct pathogenesis from adult forms and often involves comorbidities. This review highlights updated understanding of its characteristics, pathogenesis, and treatments for better clinical management.
Area of Science:
- Dermatology
- Pediatric Immunology
- Systemic Inflammatory Diseases
Background:
- Psoriasis is a chronic inflammatory systemic disease primarily affecting the skin.
- It frequently involves comorbidities and significantly impacts patients' quality of life.
- One-third of psoriasis cases begin in childhood, with unique associated medical conditions.
Purpose of the Study:
- To summarize the clinical characteristics of pediatric psoriasis.
- To focus on updated concepts of pathogenesis in pediatric psoriasis.
- To review current and emerging treatment strategies for pediatric psoriasis.
Main Methods:
- Literature review summarizing clinical characteristics, pathogenesis, and treatments.
- Focus on recent advancements and distinct aspects of pediatric psoriasis.
- Analysis of off-label treatment use and emerging biologic therapies.
Main Results:
- Pediatric psoriasis exhibits distinct clinical characteristics and pathogenesis compared to adult psoriasis.
- Current treatments are often off-label, with limited specific research for children.
- Biologic therapies are increasingly being explored and applied in pediatric cases.
Conclusions:
- Understanding the unique aspects of pediatric psoriasis is crucial for effective management.
- Further research is needed to support evidence-based, targeted treatments for children.
- This review aims to improve clinicians' understanding and management of pediatric psoriasis.
Abstract:
Psoriasis is a chronic inflammatory systemic disease primarily affecting the skin, but which often involves considerable comorbidities as well. One-third of psoriasis cases start during childhood. In pediatric psoriasis, an association with several medical comorbidities is also indicated. Furthermore, because of its chronic nature and frequent relapses, psoriatic patients tend to require long-term treatment and experience negative impacts on their quality of life. Considering the different clinical characteristics of pediatric psoriasis, it has recently been presented that the pathogenesis of pediatric psoriasis is distinct from adult psoriasis. Treatment for pediatric psoriasis usually involves the same methods as for adults. However, most treatments in pediatric psoriasis are used off-label and research in this regard is still lacking. Targeted therapies involving newly developed biologics are also increasingly being applied to psoriasis in children. This review summarizes the clinical characteristics of pediatric psoriasis and focuses mainly on the updated concepts of pathogenesis and treatments in pediatric psoriasis. This was undertaken to widen the understanding of these relevant aspects and to provide better management of pediatric psoriasis by clinicians.
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