Related Experiment Video
Updated: Oct 22, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors
Małgorzata Koziarska-Rościszewska1, Anna Gluba-Brzózka1, Beata Franczyk1
1Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, Poland.
Insights
High-sensitivity C-reactive protein (hsCRP) is a simple test that can identify patients at risk for cardiovascular disease (CVD) and metabolic disorders. hsCRP levels correlate with age, obesity, and dyslipidemia, and may be influenced by vitamin D levels.
Area of Science:
- Biochemistry
- Clinical Medicine
- Public Health
Background:
- Chronic inflammation is implicated in cardiovascular disease (CVD) development.
- A simple, primary care-accessible test is needed to identify patients at risk.
- High-sensitivity C-reactive protein (hsCRP) is a potential biomarker for inflammation.
Purpose of the Study:
- To investigate the associations between hsCRP levels and various risk factors for CVD.
- To determine if hsCRP can be used as a screening tool in primary care.
Main Methods:
- Cross-sectional study analyzing hsCRP levels.
- Statistical correlation analysis with factors including age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D, and existing CVDs.
- Comparison of hsCRP levels in patients with and without specific metabolic disorders and CVDs.
Main Results:
- Significant positive correlations found between hsCRP and age, BMI, waist circumference, dyslipidemia, and glycemia.
- Significant negative correlation observed between hsCRP and vitamin D-25(OH)D.
- hsCRP levels were significantly higher in patients with CVD, hypertension, diabetes, or visceral obesity.
Conclusions:
- The hsCRP test is a valuable tool for identifying patients at risk of metabolic disorders and CVD in primary care settings.
- Vitamin D concentration may play a role in modulating systemic inflammation as indicated by hsCRP levels.
Background:
Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reactive protein (hsCRP) with selected factors-age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D-25(OH)D, cardiovascular diseases (CVD), coronary heart disease, cerebrovascular disease, and hypertension.
Results:
Statistically significant correlations were found between hsCRP and the following: age (rs = 0.304, p = 0.0000); gender (female) (p = 0.0173); BMI (rs = 0.295, p = 0.0001); waist circumference (rs = 0.250, p = 0.0007); dyslipidemia (p = 0.0159); glycemia (rs = 0.173, p = 0.0207); and significant negative correlations between hsCRP and 25(OH)D (rs = -0.203, p = 0.0065). In patients with CVD, hypertension, diabetes, or visceral obesity, hsCRP was significantly higher than in the subgroup without these disorders. There was a statistically significant relationship between hsCRP and the number of the metabolic syndrome elements (p = 0.0053).
Conclusions:
The hsCRP test seem to be a simple test that may be used at the primary care level to identify patients at risk of metabolic disorders, CVD, and hypertension. Vitamin D concentration may be a determining factor of systemic inflammation (it may have a modulating effect).
More Related Videos
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:19Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
01:24Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:26Coronary Artery Disease IV: Preventive Measures