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Updated: Oct 22, 2025
09:17
Characterization of the Effects of Migrastatic Inhibitors on 3D Tumor Spheroid Invasion by High-resolution Confocal Microscopy
Published on: September 16, 2019
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Are We Ready for Migrastatics?
Jonathan Solomon1, Magdalena Raškova2,3, Daniel Rösel2,3
1Cell Migration and Invasion Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
Cells
|August 27, 2021
Summary
Metastasis causes most cancer deaths, yet therapies focus elsewhere. Metastasis-free survival (MFS) is a new endpoint, shifting focus to anti-metastasis drug development for better cancer treatment.
Area of Science:
- Oncology
- Translational Cancer Research
Background:
- Metastasis is the primary cause of cancer mortality in solid tumors.
- Current cancer research and drug development have historically prioritized tumor proliferation over metastasis.
- Focusing on invasion and metastasis represents a significant advancement in cancer investigation.
Purpose of the Study:
- To highlight the importance of metastasis-free survival (MFS) as a novel primary endpoint in clinical trials.
- To advocate for a paradigm shift in cancer therapeutics research and development towards anti-metastasis strategies.
- To explore the potential application of MFS as an endpoint in various solid cancers.
Main Methods:
- Review of recent FDA approval of MFS as a primary endpoint.
- Analysis of clinical trials utilizing MFS as an endpoint or examining anti-metastatic strategies.
- Discussion of the implications of MFS for evaluating anti-metastatic drug efficacy.
Main Results:
- Metastasis-free survival (MFS) has been approved by the FDA as a novel primary endpoint.
- MFS is being used to evaluate prognosis in specific cancers like prostate cancer and soft tissue sarcoma.
- This shift allows for a more accurate assessment of anti-metastatic drug effectiveness compared to tumor shrinkage.
Conclusions:
- The adoption of MFS as a primary endpoint facilitates a crucial shift towards developing effective anti-metastatic therapies.
- Anti-metastasis drugs, potentially combined with standard therapies, offer a promising avenue for improving patient outcomes.
- Intensified research into metastasis prevention and anti-metastatic properties is poised to define the future of cancer translational research.
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