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Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
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Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
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Updated: Oct 22, 2025

Characterization of the Effects of Migrastatic Inhibitors on 3D Tumor Spheroid Invasion by High-resolution Confocal Microscopy
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Are We Ready for Migrastatics?

Jonathan Solomon1, Magdalena Raškova2,3, Daniel Rösel2,3

  • 1Cell Migration and Invasion Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

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Summary
This summary is machine-generated.

Metastasis causes most cancer deaths, yet therapies focus elsewhere. Metastasis-free survival (MFS) is a new endpoint, shifting focus to anti-metastasis drug development for better cancer treatment.

Keywords:
cancer metastasisclinical trialsmetastasis inhibitormetastasis-free survivalresearch and development

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Area of Science:

  • Oncology
  • Translational Cancer Research

Background:

  • Metastasis is the primary cause of cancer mortality in solid tumors.
  • Current cancer research and drug development have historically prioritized tumor proliferation over metastasis.
  • Focusing on invasion and metastasis represents a significant advancement in cancer investigation.

Purpose of the Study:

  • To highlight the importance of metastasis-free survival (MFS) as a novel primary endpoint in clinical trials.
  • To advocate for a paradigm shift in cancer therapeutics research and development towards anti-metastasis strategies.
  • To explore the potential application of MFS as an endpoint in various solid cancers.

Main Methods:

  • Review of recent FDA approval of MFS as a primary endpoint.
  • Analysis of clinical trials utilizing MFS as an endpoint or examining anti-metastatic strategies.
  • Discussion of the implications of MFS for evaluating anti-metastatic drug efficacy.

Main Results:

  • Metastasis-free survival (MFS) has been approved by the FDA as a novel primary endpoint.
  • MFS is being used to evaluate prognosis in specific cancers like prostate cancer and soft tissue sarcoma.
  • This shift allows for a more accurate assessment of anti-metastatic drug effectiveness compared to tumor shrinkage.

Conclusions:

  • The adoption of MFS as a primary endpoint facilitates a crucial shift towards developing effective anti-metastatic therapies.
  • Anti-metastasis drugs, potentially combined with standard therapies, offer a promising avenue for improving patient outcomes.
  • Intensified research into metastasis prevention and anti-metastatic properties is poised to define the future of cancer translational research.