Related Experiment Video
Updated: Oct 22, 2025
05:30
Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
18.4K
Does Schistosoma Mansoni Facilitate Carcinogenesis?
Verena von Bülow1, Jakob Lichtenberger1, Christoph G Grevelding2
1Department of Gastroenterology, Justus Liebig University, 35392 Giessen, Germany.
Cells
|August 27, 2021
Summary
Schistosomiasis, particularly Schistosoma mansoni infection, is increasingly linked to cancer. This review explores the biomolecular mechanisms by which S. mansoni may promote hepatic and colorectal cancer development.
Area of Science:
- Parasitology
- Oncology
- Infectious Diseases
Background:
- Schistosomiasis is a major parasitic disease with significant health and economic impacts.
- Praziquantel resistance is a growing concern.
- Schistosoma haematobium is a Group 1 carcinogen; S. mansoni is IARC Group 3, with emerging evidence of carcinogenicity.
Purpose of the Study:
- To review current data on the association between Schistosoma mansoni infection and human cancer.
- To highlight new developments in understanding the biomolecular mechanisms involved.
Main Methods:
- Review of existing literature and recent research findings.
- Analysis of data from animal models and cell culture experiments.
Main Results:
- While S. mansoni is not definitively classified as a carcinogen, case reports and experimental data suggest a link to cancer.
- Evidence indicates S. mansoni may predispose to or promote hepatic and colorectal cancers.
Conclusions:
- Schistosoma mansoni infection warrants further investigation for its role in cancer development.
- Understanding the biomolecular mechanisms is crucial for potential therapeutic strategies.
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